Clinical Dermatology Review

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 1  |  Issue : 2  |  Page : 37--40

Comparison of efficacy of oral azithromycin with oral minocycline in the treatment of acne vulgaris


Vidyadhar R Sardesai1, Yashodhara T Deka2 
1 Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth University Medical College, Pune, Maharashtra, India
2 Department of Dermatology, James Paget University Hospital, Gorleston-on-Sea, Great Yarmouth, NR31 6LA, UK

Correspondence Address:
Vidyadhar R Sardesai
102 Alliance Nakshatra, 48 Tulshibagwale Colony, Sahakar Nagar No. 2, Pune - 411 009, Maharashtra
India

Background: Acne vulgaris is a common skin disease seen primarily in adolescents and young adults. As the treatment involves long-term therapy with antibiotics, an agent with a long half-life can be very useful in increasing the compliance. Objectives: The objective of this study was to evaluate the efficacy of a pulse dose of azithromycin and compare it with daily dose of minocycline in the treatment of acne vulgaris. Materials and Methods: This prospective, randomized, open-label, comparative study was conducted on sixty patients with moderate-to-moderately severe (Grade II and III) acne vulgaris. Patients were randomly assigned to two treatment groups, A and B. Patients in Group A received 50 mg minocycline orally daily whereas patients in Group B were given 500 mg azithromycin orally once a day for 3 consecutive days/week. Both the groups were advised topical application of 2.5% topical benzoyl peroxide gel in the night. The total duration of treatment was 3 weeks. All the patients were evaluated at the end of 3 weeks. Statistical analysis was done using Wilcoxon signed-rank test and Mann–Whitney U-test. Results: Group A showed a reduction in lesional count of 39.7% for noninflammatory papules, 65.11% for inflammatory papules, and 52.22% for pustules. Similarly, Group B showed 30.39%, 54.69%, and 57.76% reduction in lesional count for noninflammatory papules, inflammatory papules, and pustules, respectively. Conclusions: Both minocycline and azithromycin were equally effective and safe for the treatment of acne vulgaris.


How to cite this article:
Sardesai VR, Deka YT. Comparison of efficacy of oral azithromycin with oral minocycline in the treatment of acne vulgaris.Clin Dermatol Rev 2017;1:37-40


How to cite this URL:
Sardesai VR, Deka YT. Comparison of efficacy of oral azithromycin with oral minocycline in the treatment of acne vulgaris. Clin Dermatol Rev [serial online] 2017 [cited 2020 Oct 26 ];1:37-40
Available from: https://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2017;volume=1;issue=2;spage=37;epage=40;aulast=Sardesai;type=0