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Year : 2018  |  Volume : 2  |  Issue : 2  |  Page : 87-90

Waldenstrom macroglobulinemia with herpes zoster, a case report and review literature

1 Lab Oncology Unit, Dr. BRAI-RCH, New Delhi, India
2 Department of Medical Oncology, Dr. BRAI-RCH, New Delhi, India
3 Dr. R. P Centre for Ophthalamic Sciences, All Institute of Medical Sciences, New Delhi, India
4 Department of Engineering Management [student], RMIT University, Victoria, Melbourne, Australia
5 Department of Pathology, All Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Amar Ranjan
R. No. 422, Lab Oncology, Dr. BRAI-RCH, AIIMS, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CDR.CDR_43_17

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Waldenstrom macroglobulinemia (WM) is a variant of lymphoplasmacytic lymphoma. In WHO classification of hematolymphoid malignancy 2016, WM has been placed in between lymphoma and plasma cell myeloma under the broad heading “Neoplasms of mature lymphocytes”. This is a rare and slowly progressive disorder, which needs therapy only when symptoms appear. The average age of diagnosis is 60–70 years. WM may progress to lymphoma in 2% cases per year. Here, we are discussing a case of WM having typical findings of this rare disease, who presented with 10%–12% plasma cell in bone marrow aspirate smear, high immunoglobulin M, high beta 2 microglobulin, bilateral axillary lymphadenopathy and gastrointestinal bleeding. At present, the patient is on chlorambucil plus prednisolone therapy and is doing well. Typically, this case presented with lesions of herpes zoster, which makes this case further uncommon.

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