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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 68-71

Association of lichen planus with dyslipidemia: A comparative, cross-sectional study


Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India

Correspondence Address:
Neelakandhan Asokan
Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CDR.CDR_10_18

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Context: Lichen planus (LP) is an idiopathic T-cell-mediated inflammatory disorder. Chronic inflammation may result in derangement of lipid metabolism. Some studies have shown that prevalence of dyslipidemia is more among patients with LP, whereas other studies have not supported this hypothesis. Aims: The aim of this study is to find out if there is any association between LP and dyslipidemia. Settings and Design: The study was conducted at the dermatology outpatient department of a tertiary care hospital; this was a comparative, cross-sectional study. Subjects and Methods: Forty-seven patients with LP aged 20 years or more attending the dermatology department of a tertiary care hospital were recruited for the study. Comparison group consisted of 47 age- and sex-matched patients with skin infections of <1 month duration. Fasting lipid profile of all participants was estimated. Proportion of patients with dyslipidemia in both groups was compared using Chi-square test. Student's t-test for equality of means and Levene's test for equality of variances were used to compare the lipid profile values in both groups. Statistical Analysis Used: Chi-square test, Student's t-test for equality of means, and Levene's test for equality of variances. Results: Dyslipidemia was observed among 30 (63.8%) patients in the LP group and among 23 (48.9%) patients in the comparison group (P = 0.145; odds ratio = 1.84; 95% confidence interval = 0.81–4.2). There was no significant difference in mean serum cholesterol (P = 0.096), triglycerides (P = 0.318), high-density lipoprotein (HDL) (P = 0.901), and low-density lipoprotein (LDL) (P = 0.077) between the two groups. Levene's test of equality of variances showed that differences in the variability between patients in the LP and in the comparison group were significant for serum cholesterol values (P = 0.036), but not for serum triglycerides (P = 0.821), HDL (P = 0.343), and LDL (P = 0.841). Conclusions: Although the prevalence of dyslipidemia was more among patients with LP, it was not significant at 5% level.


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