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CASE REPORT
Year : 2018  |  Volume : 2  |  Issue : 1  |  Page : 25-27

Bowenoid papulosis of genitalia responding to topical 5-Fluorouracil


1 Department of Dermatology, Venereology and Leprosy, ESIC Medical College and PGIMSR, Bengaluru, India
2 Skin Laser Centre, New Delhi, India
3 Department of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka, India
4 Department of Dermatology, Venereology and Leprosy, Sri Siddhartha Medical College, Tumkur, Karnataka, India

Correspondence Address:
Meenakshi Kapoor
B-5/35, Sector-7, Rohini, New Delhi - 110 085
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CDR.CDR_11_17

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Bowenoid papulosis (BP), a rare disease with malignant potential, is a distinct clinicopathological entity strongly associated with human papillomavirus (HPV) infection. We described an adult male presenting with well defined, purplish papules of varying size with verrucous to smooth surface distributed discretely over medial side of the left thigh, scrotum, and penile shaft. Histopathology showed focal areas of full thickness epidermal atypia comprising irregularly arranged nuclei which are large, hyperchromatic, and crowded at few places. Pap smear from spouse showed inflammatory infiltrate with moderate-to-severe dysplasia. The patient was treated with topical 5-fluorouracil. Excellent response was noticed at the end of 2 weeks. A patient with BP should be thoroughly educated regarding HPV infection and emphasis should be on prevention. Female patients or sexual partners of male patient with BP are at the risk of developing cervical cancer and hence should be followed with regular cytologic, colposcopic, and histologic examinations.


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